2 ^nd International Conference on Pathology and Pathological Disorders March 24-25, 2021 Madrid, Spain

Biography:

Dr.Azimi khatibani has completed his Medical Specialty  at the age of 29  years  (in 2011) and  his  Medical Degree at age of 25 from TehranUniversity of Medical Sceinces,Iran. He is the assisstant professor  of  pathology  in Zabol university of medical sciences .He has served  in the most deprived and underserved area of Iran ( Zabol) since 2013.He is coolaborating with  the  research centers of shahid beheshti university of medical sciences, iran  since 2019.

Abstract:

Pathology education conventional methods have been disrupted by the Corona-Virus Disease 2019 (COVID-19) outbreak, compelling a re-evaluation of the means of educational interactions from the undergraduate to the postgraduate level.

The challenges are partly due to transferring from face to face teaching to virtual education. Other reasons are shifting away from discipline-based teaching to organ-system based in medical curriculum and additional pressures on pathology faculties, such as increased demand for pathology services, lack of time, and learning resources.

Keeping the national standards in pathology education even in the constant disruptions from pandemic outbreaks are current challenges. Pathology expertise will need to use emergent technologies in providing educational material to ensure quality pathology education. However, virtualization of pathology education produces a value of digital pathology and web-based pathology training materials.

 This article explores how the COVID-19 outbreak has challenged pathology education. It also has examined the potential implications of virtual technologies on modern pathology education for the future of pathology competency learning and assessment. We need new innovative strategies and we suggested the following steps to take advantage of the current opportunity to meet the challenges: evaluate the available digital training materials for formal pathology education, Invest in the virtual infrastructure for competency based pathology education, expand student/residents exposure to pathology educational cases through virtual platforms; Apply Digital pathology Solutions for Virtual pathology Education.

Biography:

Joanna Sawicka is a fourth year medical student of College of Medical Sciences of University of Rzeszów.
Aneta StabryÅ‚a is a fourth year medical student of College of Medical Sciences of University of Rzeszów.

Abstract:

Introduction:

Macroadenomas are common beningn hypophyseal tumours, that may cause disruption of visual field [1] or other symptoms by mass effect [2]. Following the diagnosis a trans-sphenoid tumor removal is the treatment of choice in patients with visual field impairment [3]. We would like to present a rare case of a patient with ischemic stroke being an macroadenoma resection complication.

Case report:

A 47-year old female was admitted to the Clinic of Neurosurgery for removal of a nonfunctioning macroadenoma of pituitary gland causing progressive decrement of visual field. A trans-sphenoidal resection was performed with the tumor incomplete resection. Sudden dysarthria and right side hemiplegia have been observed in 24h post-operative period. The MRI revealed an ischemic area of left subcortical region and intrapituitary hemorrhage with substantial regional edema. Several days after surgery prominent mixed aphasia appeard and enlargement of ischemic area to entire left MCA supply territory. Compression of distal ICA or proximal MCA by sudden volumetric expansion of the macroadenoma as a result of bleeding inside the tumor was considered the most probable mechanism of ischemia.

Conclusions:

Transsphenoidal surgery is a procedure of choice for removal of the pituitary macroadenoma. It is considered safe, but occasionally serious complications of surgery can occur, with pituitary apoplexy being one of them. The postoperative hemorrhage into residual adenoma may cause compression of adjacent structures including optic chiasm, cranial nerves and distal portion of ICA. The latter complication is extremally rare and was reported in only few case reports.

Biography:

Nidhi Anand,Department of Pathology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow UP, India

Abstract:

INTRODUCTION AND OBJECTIVE: The BRAF^V600E is a common mutation in papillary thyroid carcinoma (PTC) associated with aggressive behaviour. In Bethesda category III, IV and V of thyroid cytology, the use of immunocytochemistry (ICC) and molecular testing is recommended to refine the diagnosis. The present study aimed to assess BRAF^V600Eexpression in thyroid aspirates and corresponding histology specimens and to evaluate the diagnostic efficacy of conventional FNAC vs FNAC with BRAF^V600E testing in Bethesda category IV and V, VI of PTC.

METHODOLOGY: This study prospectively enrolled 40 cases with thyroid aspirate of Bethesda category IV and V, IV of PTC. IHC for BRAF^V600E was performed on cell blocks and corresponding histology sections. The diagnostic efficacy in the diagnosis of these lesions was assessed.

RESULTS: Our results included 25 lesions in category IV and 15 in category V &VI. The diagnostic sensitivity of ICC in thyroid aspirates was 81.82%, specificity 100%, positive predictive value 100%, negative predictive value 93.55% and accuracy 95%.

DISCUSSION & CONCLUSION: In category III, IV and V  BRAF^V600Emutation analysis is needed to better define the extent the initial surgery. BRAF^V600Emutation can be druggable using BRAF^V600E inhibitor molecules in some selected patients that improves disease free and overall survival in BRAF^V600E positive cases. All BRAF^V600E negative cases on cytology with Bethesda category IV, V and VI; BRAF^V600E testing should be repeated on corresponding histology samples to ensure accurate mutation status.

Biography:

Dr. Subrat Chandra has completed his MD from Himalyan Institute of Medical Sciences, Jolly Grant,Dehradun ,India in year 2006 at the age of 27 years and did senior residency and as lecturer from UP Rural Institute of medical Sciences, Saifai, Etawah UP,India. He is the Professor of Pathology at Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India. He is incharge and Head of Department of Transfusion Medicine  laboratory. He has published more than 15 papers in reputed journals and has been serving as member Indian Academy of Cytologists- U.P. Chapter and Indian association of Pathology and Microbiology.

Dr. Subrat Chandra, Professor of Pathology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Vibhuti Khand, Gomti Nagar, Lucknow-226010.

Abstract:

Introduction and Objectives: Soft tissue neoplasms (STNs) are uncommon tumors and present with difficulties in diagnosis and classification. Assigning a pathologic type or grade to an individual sarcoma as a means of predicting clinical behavior is often difficult.

Methods & Materials: The objective of this study was to assess the diagnostic value of cytology with cell-block immunocytochemistry as an adjunct to cytomorphology in the diagnosis and sub typing soft tissue tumors. The study included case series of 60 cases of clinically suspected malignant STTsin which FNA was done from swellings,smears were prepared from aspirated material and sample was also procured for cell-block and cell block immunocytochemistry (CB- ICC).

Results: The study included 60 cases of clinically suspected malignant STNs. Males were more commonly affected with maximum cases presenting in fifth to sixth decade. Histopathological confirmation in 49 cases, gave a diagnostic accuracy of 93.33%, with sensitivity of 95.12% and specificity of 75%. Spindle cell tumors (47%) accounted for the majority of the cytodiagnosed cases in our series. Sub-typing on cytomorphology alone was possible in 28.20% cases, which further increased up to 64.10% with application of CB-ICC.

Conclusion: The present study concluded that FNAC can be used as a reliable diagnostic tool for preoperative triaging of benign and malignant STN with fair sensitivity, specificity, and accuracy, and if supplemented with CB-ICC, even further sub-typing is possible in good number of cases.