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Subrat Chandra

Department of Pathology, Dr.Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India

Title: Malignant soft tissue neoplasms diagnosed on cytology and with cell block immunocytochemistry

Biography

Biography: Subrat Chandra

Abstract

Introduction and Objectives: Soft tissue neoplasms (STNs) are uncommon tumors and present with difficulties in diagnosis and classification. Assigning a pathologic type or grade to an individual sarcoma as a means of predicting clinical behavior is often difficult.

Methods & Materials: The objective of this study was to assess the diagnostic value of cytology with cell-block immunocytochemistry as an adjunct to cytomorphology in the diagnosis and sub typing soft tissue tumors. The study included case series of 60 cases of clinically suspected malignant STTsin which FNA was done from swellings,smears were prepared from aspirated material and sample was also procured for cell-block and cell block immunocytochemistry (CB- ICC).

Results: The study included 60 cases of clinically suspected malignant STNs. Males were more commonly affected with maximum cases presenting in fifth to sixth decade. Histopathological confirmation in 49 cases, gave a diagnostic accuracy of 93.33%, with sensitivity of 95.12% and specificity of 75%. Spindle cell tumors (47%) accounted for the majority of the cytodiagnosed cases in our series. Sub-typing on cytomorphology alone was possible in 28.20% cases, which further increased up to 64.10% with application of CB-ICC.

Conclusion: The present study concluded that FNAC can be used as a reliable diagnostic tool for preoperative triaging of benign and malignant STN with fair sensitivity, specificity, and accuracy, and if supplemented with CB-ICC, even further sub-typing is possible in good number of cases.