Hina Naushad Qureishi
University of Nebraska medical Center, USA
Title: Genomic signatures in non-hodgkin lymphomas
Biography
Biography: Hina Naushad Qureishi
Abstract
The classification of B-cell and T-cell non-Hodgkin lymphoma has changed considerably over the last several decades. The currently used World Health Organization (WHO) classification system has a broader consensus among the clinical and biomedical community. However, there are still several challenges in regards to the understanding of tumor biology, clinical outcome and diagnostic accuracy in certain subtypes of lymphomas such as peripheral T-cell lymphoma (PTCL), where the diagnosis is frequently challenging even among expert hematopathologists and often time’s assessment requires additional molecular testing. Recently genome-wide high throughput techniques have greatly improved our understanding of B and T-cell lymphomas. This novel genetic information has not only aided in diagnosis, but has also revealed a landscape of critical molecular events that determine the biological and clinical behavior of a lymphoma. In this presentation, I will summarize the genetic characteristics of major subtypes of B-cell and T-cell lymphomas including diffuse large B cell lymphoma (DLBCL), follicular lymphoma (FL), Burkitt lymphoma (BL), and mantle cell lymphoma (MCL) and common subtypes of PTCL including angioimmunoblastic T-cell lymphoma (AITL), anaplastic T-cell lymphoma (ALCL), adult T-cell leukemia/lymphoma (ATLL) and extra-nodal NK/T cell lymphoma (ENKTL), and how can these improve precision in diagnosis and inform prognosis.