R. Rajesh Singh
University of Texas, USA
Title: Rapid progress of next generation sequencing technology: Implications for implementation in clinical diagnostic laboratories
Biography
Biography: R. Rajesh Singh
Abstract
In the past few years, the massively parallel sequencing capabilities of NGS have found widespread acceptance for clinical genomics in molecular diagnostic laboratories. Due to rapid progress, the underlying technology and the associated informatics is constantly evolving resulting in considerable process improvements in relatively short durations. Although desirable, these constant upgrades pose a challenge for clinical sequencing assays being used for clinical purposes due to the need of through validation before implementation. Here, in the context of a CAP and CLIA accredited molecular diagnostic laboratory the advantages and challenges posed by the constant upgrades for routine NGS testing of solid tumors and hematological malignancies will be presented. The progress in the wet bench and informatics portions of major NGS platforms will be highlighted.