Biography
Haodong Xu received his MD, MS, and PhD from Suzhou Medical College. He subsequently completed a residency in Anatomic and Clinical Pathology at Barnes-Jewish Hospital/Washington University School of Medicine, and a fellowship at the Armed Forces Institute of Pathology. He is currently Professor of Head and Neck and Cardiothoracic Pathology at the David Geffen School of Medicine at UCLA. In addition, his interests also include molecular mechanisms of lung, head and neck tumors, and fibrosing interstitial pneumonia, and his basic research is focused on delineating the regulation mechanisms of voltage-gated cardiac ion channels.
Research Interest
Autopsy, Cardiopulmonary, and Head & Neck
Biography
Dr. Luo been studying molecular pathology related to human malignancies in the last 27 years. Currently, he is a Professor of Pathology and Director of High Throughput Genome Center at University of Pittsburgh. In the last 15 years, Dr. Luo has been largely focusing on genetic and molecular mechanism of human prostate and hepatocellular carcinomas. In this period, his group has identified and characterized several genes that are related to prostate cancer and hepatocellular carcinoma, including SAPC, myopodin, CSR1, GPx3, ITGA7, MCM7, MT1h and GPC3. He has characterized several signaling pathways that play critical role in prostate cancer development, including Myopodin-ILK-MCM7 inhibitory signaling, myopodin-zyxin motility inhibition pathway, CSR1-CPSF3 and CSR1-XIAP apoptotic pathways, MT1h-EHMT1 egigenomic signaling, ITGA7-HtrA2 tumor suppression pathway, GPx3-PIG3 cell death pathway, and AR-MCM7 oncogenic pathway. He proposed prostate cancer field effect in 2002. He is one of the pioneers in utilizing high throughput gene expression and genome analyses to analyze field effects in prostate cancer and liver cancer. He is also the first in using methylation array and whole genome methylation sequencing to analyze prostate cancer. Recently, Dr. Luo’s group found that patterns of copy number variants of certain specific genome loci are predictive of prostate cancer clinical outcomes, regardless tissue origin. His discovery of several novel fusion transcripts and their association with aggressive prostate cancer has brought significant new insight into the field of prostate cancer research. Overall, these discoveries advance our understanding on how cancer develops and behaves, and lay down the foundation for better future diagnosis and treatment of human malignancies.
Research Interest
Prostate cancer Research
Biography
K. H. Ramesh did his PhD, in Human Cancer Cytogenetics from Bangalore University, India. He trained under the guidance of world renowned geneticist Avery Sandberg, MD., at Roswell Park Cancer Institute, Buffalo, USA. He is Board Certified in Clinical Cytogenetics; currently a Diplomate of the American Board of Medical Genetics and Genomics, and Fellow of the American College of Medical Genetics and Genomics. At present he is the Director of Cancer CytoGenomics and Associate Professor of Pathology at Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, USA. He has over 25 years of experience in Human Cancer Genetics
Research Interest
Pathology, Human Cancer Genetics